BAIT
RAD51
rhp51, SPAC644.14c
RecA family recombinase Rad51/Rhp51
GO Process (9)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- double-strand break repair via homologous recombination [ISS]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IGI]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA repair synthesis [IMP]
- meiotic gene conversion [IDA]
- mitotic recombination [IGI]
- strand invasion [IDA]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
AGO1
csp9, SPCC736.11
argonaute
GO Process (12)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromatin silencing by small RNA [IMP]
- co-transcriptional gene silencing by RNA interference machinery [IMP]
- conversion of ds siRNA to ss siRNA involved in RNA interference [IMP]
- heterochromatin assembly involved in chromatin silencing by small RNA [IMP]
- mitotic sister chromatid segregation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of chromatin silencing at centromere [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II.
Heterochromatin comprises tightly compacted repetitive regions of eukaryotic chromosomes. The inheritance of heterochromatin through mitosis requires RNA interference (RNAi), which guides histone modification during the DNA replication phase of the cell cycle. Here we show that the alternating arrangement of origins of replication and non-coding RNA in pericentromeric heterochromatin results in competition between transcription and replication in Schizosaccharomyces pombe. Co-transcriptional ... [more]
Nature Nov. 03, 2011; 479(7371);135-8 [Pubmed: 22002604]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID