A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Brc1-dependent recovery from replication stress.

Bass KL, Murray JM, O'Connell MJ

Brc1 is a multi-BRCT domain protein in Schizosaccharomyces pombe that is required for resistance to chronic replicative stress, but whether this reflects a repair or replication defect is unknown and the subject of this study. Rad52 is a homologous recombination protein that loads the Rad51 recombinase at resected dsDNA breaks and is also recruited to stalled replication forks, where it ... [more]

Unknown Feb. 24, 2012; 0(0); [Pubmed: 22366461]

Throughput

Low Throughput

Ontology Terms

phenotype: protein/peptide accumulation (APO:0000149)

Additional Notes

double mutants show increased sensitivity to HU and reduced formation of Rad52 foci compared to a brc1 single mutant

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ORC1 BRC1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Bass KL (2012)	Low	-	BioGRID	642588
ORC1 BRC1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Yadav RK (2017)	Low	-	BioGRID	2333489

Curated By

BioGRID

Interaction Summary

BRC1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

ORC1