BRC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAD52
Gene Ontology Biological Process
- DNA recombinase assembly [NAS]
- double-strand break repair via homologous recombination [IGI]
- gene conversion at mating-type locus, DNA repair synthesis [IMP]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IMP]
- meiotic DNA repair synthesis [IMP]
- mitotic recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Brc1-dependent recovery from replication stress.
Brc1 is a multi-BRCT domain protein in Schizosaccharomyces pombe that is required for resistance to chronic replicative stress, but whether this reflects a repair or replication defect is unknown and the subject of this study. Rad52 is a homologous recombination protein that loads the Rad51 recombinase at resected dsDNA breaks and is also recruited to stalled replication forks, where it ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- deletion of brc1 suppresses the hyper-recombination phenotype seen in an srs2 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BRC1 RAD52 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - |
Curated By
- BioGRID