BAIT
NRXN1
Hs.22998, PTHSL2, SCZD17
neurexin 1
GO Process (38)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [IMP]
- angiogenesis [ISS]
- axon guidance [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cerebellar granule cell differentiation [ISS]
- establishment of protein localization [ISS]
- extracellular matrix organization [TAS]
- gamma-aminobutyric acid receptor clustering [ISS]
- gephyrin clustering [ISS]
- guanylate kinase-associated protein clustering [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- learning [IMP]
- negative regulation of filopodium assembly [ISS]
- neuroligin clustering [ISS]
- neuromuscular process controlling balance [IMP, ISS]
- neuron cell-cell adhesion [ISS, TAS]
- neuronal signal transduction [TAS]
- neurotransmitter secretion [ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synapse maturation [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein complex assembly involved in synapse maturation [ISS]
- protein localization to synapse [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse assembly [ISS]
- synaptic transmission [ISS]
- synaptic vesicle clustering [ISS]
- vocal learning [IMP]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MACF1
ABP620, ACF7, MACF, OFC4
microtubule-actin crosslinking factor 1
GO Process (8)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- Golgi to plasma membrane protein transport [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of axon extension [IDA]
- regulation of epithelial cell migration [ISS]
- regulation of focal adhesion assembly [ISS]
- regulation of microtubule-based process [IMP]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.
Large proteins have multiple domains that are potentially capable of binding many kinds of partners. It is conceivable, therefore, that such proteins could function as an intricate framework of assembly protein complexes. To comprehensively study protein-protein interactions between large KIAA proteins, we have constructed a library composed of 1087 KIAA cDNA clones based on prior functional classifications done in silico. ... [more]
Genome Res. Nov. 01, 2002; 12(11);1773-84 [Pubmed: 12421765]
Throughput
- Low Throughput
Curated By
- BioGRID