BAIT
LRP4
CLSS, LRP-4, LRP10, MEGF7, SOST2
low density lipoprotein receptor-related protein 4
GO Process (14)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- dendrite morphogenesis [ISS]
- extracellular matrix organization [TAS]
- kidney development [IDA]
- limb development [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of ossification [IMP]
- positive regulation of presynaptic membrane organization [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein heterotetramerization [ISS]
- skeletal muscle acetylcholine-gated channel clustering [ISS]
- synapse organization [ISS]
- synaptic growth at neuromuscular junction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DFNB31
CIP98, PDZD7B, USH2D, WHRN, WI, RP11-9M16.1
deafness, autosomal recessive 31
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.
Large proteins have multiple domains that are potentially capable of binding many kinds of partners. It is conceivable, therefore, that such proteins could function as an intricate framework of assembly protein complexes. To comprehensively study protein-protein interactions between large KIAA proteins, we have constructed a library composed of 1087 KIAA cDNA clones based on prior functional classifications done in silico. ... [more]
Genome Res. Nov. 01, 2002; 12(11);1773-84 [Pubmed: 12421765]
Throughput
- Low Throughput
Curated By
- BioGRID