BAIT
MEGF10
EMARDD
multiple EGF-like-domains 10
GO Process (7)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
- homotypic cell-cell adhesion [IDA]
- muscle cell development [IMP]
- regulation of muscle cell differentiation [IMP]
- regulation of skeletal muscle tissue development [IMP]
- skeletal muscle satellite cell activation [ISS]
- skeletal muscle satellite cell differentiation [IMP]
- skeletal muscle satellite cell proliferation [ISS]
Homo sapiens
PREY
GRB10
GRB-IR, Grb-10, IRBP, MEG1, RSS
growth factor receptor-bound protein 10
GO Process (8)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- insulin receptor signaling pathway [ISS, TAS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of glucose import [ISS]
- negative regulation of glycogen biosynthetic process [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- positive regulation of phosphorylation [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- response to insulin [ISS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.
Large proteins have multiple domains that are potentially capable of binding many kinds of partners. It is conceivable, therefore, that such proteins could function as an intricate framework of assembly protein complexes. To comprehensively study protein-protein interactions between large KIAA proteins, we have constructed a library composed of 1087 KIAA cDNA clones based on prior functional classifications done in silico. ... [more]
Genome Res. Nov. 01, 2002; 12(11);1773-84 [Pubmed: 12421765]
Throughput
- Low Throughput
Curated By
- BioGRID