RERE
Gene Ontology Biological Process
- branching morphogenesis of a nerve [IMP]
- cerebellar Purkinje cell layer maturation [IMP]
- cerebellar granule cell precursor proliferation [IMP]
- cerebellum development [IMP]
- chromatin remodeling [IPI]
- dendrite morphogenesis [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- radial glia guided migration of Purkinje cell [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATN1
Gene Ontology Biological Process
- cell migration [IDA]
- maintenance of cell polarity [IDA]
- negative regulation of nucleic acid-templated transcription [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- neuron apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- toxin metabolic process [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.
Atrophins are evolutionarily conserved proteins that are thought to act as transcriptional co-repressors. Mammalian genomes contain two atrophin genes. Dominant polyglutamine-expanded alleles of atrophin 1 have been identified as the cause of dentatorubralpallidoluysian atrophy, an adult-onset human neurodegenerative disease with similarity to Huntington's. In a screen for recessive mutations that disrupt patterning of the early mouse embryo, we identified a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID