HDAC6
Gene Ontology Biological Process
- Hsp90 deacetylation [IMP]
- aggresome assembly [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to topologically incorrect protein [IMP]
- histone deacetylation [IDA, ISS]
- intracellular protein transport [IMP]
- lysosome localization [IMP]
- macroautophagy [IMP]
- misfolded or incompletely synthesized protein catabolic process [IMP]
- negative regulation of hydrogen peroxide metabolic process [IC]
- negative regulation of oxidoreductase activity [IC]
- negative regulation of protein complex disassembly [IMP]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- peptidyl-lysine deacetylation [IMP]
- polyubiquitinated misfolded protein transport [IMP]
- positive regulation of chaperone-mediated protein complex assembly [IMP]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of hydrogen peroxide-mediated programmed cell death [IDA]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of signal transduction [IMP]
- protein deacetylation [IMP]
- regulation of androgen receptor signaling pathway [TAS]
- regulation of gene expression, epigenetic [IMP]
- regulation of microtubule-based movement [IC]
- regulation of receptor activity [IMP]
- response to growth factor [IMP]
- response to misfolded protein [IMP]
- response to organic substance [IMP]
- response to toxic substance [IMP]
- tubulin deacetylation [IDA, ISS]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- alpha-tubulin binding [IDA]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- dynein complex binding [IDA]
- enzyme binding [ISS]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- microtubule binding [IDA, ISS]
- polyubiquitin binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- tubulin deacetylase activity [IDA, ISS]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- alpha-tubulin binding [IDA]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- dynein complex binding [IDA]
- enzyme binding [ISS]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- microtubule binding [IDA, ISS]
- polyubiquitin binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- tubulin deacetylase activity [IDA, ISS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- aggresome [IDA]
- axon [ISS]
- caveola [IDA]
- cell leading edge [IDA]
- cytoplasm [ISS]
- cytosol [ISS]
- dendrite [ISS]
- dynein complex [IDA]
- histone deacetylase complex [IDA]
- inclusion body [IDA]
- microtubule [IDA]
- microtubule associated complex [IDA]
- nucleoplasm [IDA]
- nucleus [ISS]
- perikaryon [ISS]
- perinuclear region of cytoplasm [IDA]
PRKCA
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- activation of adenylate cyclase activity [ISS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- blood coagulation [TAS]
- desmosome assembly [IMP]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- histone H3-T6 phosphorylation [IDA]
- innate immune response [TAS]
- mRNA metabolic process [TAS]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of glial cell apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle hypertrophy [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of dense core granule biogenesis [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of macrophage differentiation [ISS]
- positive regulation of mitotic cell cycle [IMP]
- protein phosphorylation [IDA]
- regulation of insulin secretion [TAS]
- regulation of platelet aggregation [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to interleukin-1 [IMP]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Targeting MYC dependence in cancer by inhibiting BET bromodomains.
The MYC transcription factor is a master regulator of diverse cellular functions and has been long considered a compelling therapeutic target because of its role in a range of human malignancies. However, pharmacologic inhibition of MYC function has proven challenging because of both the diverse mechanisms driving its aberrant expression and the challenge of disrupting protein-DNA interactions. Here, we demonstrate ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKCA HDAC6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PRKCA HDAC6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PRKCA HDAC6 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 644579 | |
| PRKCA HDAC6 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID