RNF31
Gene Ontology Biological Process
- CD40 signaling pathway [IMP]
- T cell receptor signaling pathway [ISO]
- negative regulation of necroptotic process [IGI]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- protein linear polyubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MUSK
Gene Ontology Biological Process
- long-term synaptic potentiation [ISO]
- memory [ISO]
- negative regulation of gene expression [ISO]
- neuromuscular junction development [IGI]
- peptidyl-tyrosine phosphorylation [ISO, TAS]
- positive regulation of gene expression [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein geranylgeranylation [IMP]
- positive regulation of protein phosphorylation [IMP, ISO]
- positive regulation of synaptic growth at neuromuscular junction [ISO]
- positive regulation of synaptic transmission, cholinergic [ISO]
- protein autophosphorylation [ISO]
- receptor clustering [IGI, IMP, ISO]
- regulation of synaptic growth at neuromuscular junction [IMP]
- regulation of transcription, DNA-templated [IMP]
- response to electrical stimulus [ISO]
- signal transduction [TAS]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts with the muscle-specific kinase (MuSK).
Formation of the postsynaptic membrane at the skeletal neuromuscular junction (NMJ) requires activation of the muscle-specific receptor tyrosine kinase (MuSK). Few intracellular mediators or modulators of MuSK actions are known. E3 ubiquitin ligases may serve this role, because activities of several receptor tyrosine kinases, G-protein-coupled receptors and channels are modulated by ubiquitination. Here, we report identification of a putative Ariadne-like ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID