UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BCL2L1
Gene Ontology Biological Process
- apoptotic process [IEP]
- apoptotic process in bone marrow [ISO]
- cell proliferation [ISO]
- cellular process regulating host cell cycle in response to virus [ISO]
- cellular response to alkaloid [ISO]
- cellular response to amino acid stimulus [ISO]
- cellular response to gamma radiation [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IBA, ISO]
- fertilization [ISO]
- germ cell development [ISO]
- growth [ISO]
- hepatocyte apoptotic process [ISO]
- in utero embryonic development [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA, ISO]
- male gonad development [ISO]
- mitochondrion morphogenesis [ISO]
- mitotic cell cycle checkpoint [ISO, ISS]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of establishment of protein localization to plasma membrane [ISO]
- negative regulation of execution phase of apoptosis [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- neuron apoptotic process [ISO]
- ovarian follicle development [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- regulation of apoptotic process [IDA]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of mitochondrial membrane potential [ISO]
- release of cytochrome c from mitochondria [ISO]
- response to cycloheximide [ISO]
- response to cytokine [ISO]
- response to electrical stimulus [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to inorganic substance [IEP]
- response to ischemia [IDA]
- response to lead ion [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IEP]
- response to peptide hormone [IEP]
- response to radiation [ISO]
- response to virus [ISO]
- spermatogenesis [ISO]
- suppression by virus of host apoptotic process [ISO]
Gene Ontology Molecular Function- BH domain binding [IPI]
- BH3 domain binding [ISO]
- MDM2/MDM4 family protein binding [IPI]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA]
- protein kinase binding [ISO]
- BH domain binding [IPI]
- BH3 domain binding [ISO]
- MDM2/MDM4 family protein binding [IPI]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells.
The development of doxorubicin cardiomyopathy involves apoptosis of cardiac muscle cells. This study was carried out to define the roles of two heat-shock proteins, Hsp10 and Hsp60, on doxorubicin-induced apoptosis in primary cardiomyocytes. Doxorubicin induces apoptosis of cardiomyocytes by activating mitochondria apoptosis signaling. Transducing cardiomyocytes with Hsp10 or Hsp60 with adenoviral vector suppressed the occurrence of apoptosis in the doxorubicin-treated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBC BCL2L1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID