UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EPAS1
Gene Ontology Biological Process
- angiogenesis [ISO]
- blood vessel remodeling [ISO]
- cell differentiation [ISO]
- cell maturation [ISO]
- cellular response to hypoxia [ISO, ISS]
- embryonic placenta development [ISO]
- erythrocyte differentiation [ISO]
- hemopoiesis [ISO]
- iron ion homeostasis [ISO]
- lung development [ISO]
- mitochondrion organization [ISO]
- myoblast fate commitment [ISO]
- norepinephrine metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- regulation of heart rate [ISO]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- response to hypoxia [IDA, ISO, TAS]
- response to oxidative stress [ISO]
- surfactant homeostasis [ISO]
- transcription from RNA polymerase II promoter [ISO]
- visual perception [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- histone acetyltransferase binding [ISO]
- protein heterodimerization activity [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- histone acetyltransferase binding [ISO]
- protein heterodimerization activity [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors.
Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is induced by hypoxia in oxygen-sensitive cells of the carotid body and pheochromocytoma-derived PC12 cells. TH is also regulated by the von Hippel-Lindau tumor suppressor protein (pVHL). Here, we report that induction of TH gene expression involves activation of the hypoxia-inducible transcription factors (HIFs) that interact with a specific hypoxia-responsive element ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID