CHD5
Gene Ontology Biological Process
- cerebral cortex neuron differentiation [IMP]
- histone H3-K27 trimethylation [ISO]
- histone H4 acetylation [IMP]
- negative regulation of cell proliferation [IMP]
- positive regulation of signal transduction by p53 class mediator [IMP]
- regulation of cell differentiation [IMP]
- regulation of transcription involved in cell fate commitment [IMP, ISO]
- spermatogenesis, exchange of chromosomal proteins [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
SYN2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
CHD5 is frequently deleted in neuroblastoma and is a tumor suppressor gene. However, little is known about the role of CHD5 other than it is homologous to chromatin remodeling ATPases. We found CHD5 mRNA was restricted to the brain; by contrast, most remodeling ATPases were broadly expressed. CHD5 protein isolated from mouse brain was associated with HDAC2, p66ss, MTA3 and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID