BAIT
SMAD1
AI528653, Madh1, Madr1, Mlp1, MusMLP
SMAD family member 1
GO Process (25)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- BMP signaling pathway [IGI, IMP, ISO, TAS]
- MAPK cascade [IMP, ISO]
- SMAD protein complex assembly [ISO]
- bone development [IGI]
- cardiac muscle cell proliferation [IGI, IMP]
- cartilage development [IGI]
- cellular response to BMP stimulus [IGI]
- cellular response to organic cyclic compound [IDA]
- gamete generation [IMP]
- hindbrain development [IMP]
- homeostatic process [IMP]
- mesodermal cell fate commitment [IGI]
- midbrain development [IMP]
- negative regulation of cell proliferation [IMP]
- osteoblast fate commitment [IGI]
- positive regulation of cartilage development [IDA]
- positive regulation of cell differentiation [ISO]
- positive regulation of gene expression [IMP, ISO]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IGI]
- protein phosphorylation [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to drug [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- I-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- co-SMAD binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- I-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- co-SMAD binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
GJB6
AA958971, Cx30, D14Bwg0506e
gap junction protein, beta 6
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation.
The Msx1 gene in mice has been proven to be induced by BMP (bone morphogenetic protein) proteins, and three binding sites for SMAD, an intracellular BMP signalling transducer, have already been identified in its promoter. Gel shift analyses were performed and they demonstrated that the consensus found very near the transcription start site, a region designed BP (basal promoter), is ... [more]
Biochem. J. Jan. 01, 2006; 393(0);141-50 [Pubmed: 16101586]
Throughput
- Low Throughput
Curated By
- BioGRID