BAIT
SMAD5
1110051M15Rik, AI451355, Dwf-C, Madh5, MusMLP
SMAD family member 5
GO Process (15)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IGI, TAS]
- Mullerian duct regression [ISO]
- bone development [IGI]
- cardiac muscle contraction [IMP]
- cartilage development [IGI]
- cellular response to BMP stimulus [IGI]
- cellular response to organic cyclic compound [IDA]
- erythrocyte differentiation [IMP]
- germ cell development [IMP]
- osteoblast fate commitment [IGI]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IGI]
- protein phosphorylation [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BACH1
6230421P05Rik, AI323795
BTB and CNC homology 1
GO Process (7)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [ISO]
- regulation of transcription involved in G2/M transition of mitotic cell cycle [ISO]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation.
The Msx1 gene in mice has been proven to be induced by BMP (bone morphogenetic protein) proteins, and three binding sites for SMAD, an intracellular BMP signalling transducer, have already been identified in its promoter. Gel shift analyses were performed and they demonstrated that the consensus found very near the transcription start site, a region designed BP (basal promoter), is ... [more]
Biochem. J. Jan. 01, 2006; 393(0);141-50 [Pubmed: 16101586]
Throughput
- Low Throughput
Curated By
- BioGRID