BAIT
FAF2
ETEA, UBXD8, UBXN3B
Fas associated factor family member 2
GO Process (2)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDC48
AAA family ATPase CDC48, L000000280, YDL126C
AAA ATPase; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing, in macroautophagy, PMN, RAD, ribophagy, homotypic ER membrane fusion, disassembly of Met30p from SCF complex; functional ortholog of human p97/VCP
GO Process (18)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- ER-associated misfolded protein catabolic process [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- SCF complex disassembly in response to cadmium stress [IMP]
- cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [IMP]
- endoplasmic reticulum membrane fusion [IMP]
- macroautophagy [IMP]
- mitochondria-associated ubiquitin-dependent protein catabolic process [IMP]
- mitotic spindle disassembly [IMP]
- nonfunctional rRNA decay [IMP]
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [IMP]
- piecemeal microautophagy of nucleus [IMP]
- positive regulation of histone H2B ubiquitination [IMP]
- positive regulation of protein localization to nucleus [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- retrograde protein transport, ER to cytosol [IMP]
- ribophagy [IMP]
- ribosome-associated ubiquitin-dependent protein catabolic process [IMP]
- sister chromatid biorientation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex [IDA]
- Cdc48p-Npl4p-Vms1p AAA ATPase complex [IDA]
- Doa10p ubiquitin ligase complex [IDA]
- Hrd1p ubiquitin ligase ERAD-L complex [IDA]
- RQC complex [IDA]
- cytosol [IDA]
- cytosolic large ribosomal subunit [IDA]
- endoplasmic reticulum membrane [IDA]
- mating projection tip [IDA]
- mitochondrion [IDA]
- nucleus [IDA]
Saccharomyces cerevisiae (S288c)
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The ubiquitin-like (UBX)-domain-containing protein Ubx2/ Ubxd8 regulates lipid droplet homeostasis.
Lipid droplets (LDs) are central organelles for maintaining lipid homeostasis. However, how cells control the size and number of LDs remains largely unknown. Herein, we report that Ubx2, a UBX-domain-containing protein involved in endoplasmic reticulum (ER)-associated degradation (ERAD), is crucial for LD maintenance. Ubx2 redistributes from ER to LDs when LDs start to form and enlarge during diauxic shift and ... [more]
Unknown Mar. 27, 2012; 0(0); [Pubmed: 22454508]
Throughput
- Low Throughput
Ontology Terms
- phenotype: synthetic rescue (APO:0000184) [synthetic rescue (APO:0000184)]
Additional Notes
- Ubxd8 expressed from the GPD1, but not UBX2 promoter, rescued the LD defect (Fig. 6B) and restored in ubx2 deletion mutant. In addition,Ubxd8 expression rescued the degradation defect of CPY*-HA and Deg1-GFP (Fig.3B), and the slow growth phenotype associated with ubx2 deletion mutant (Fig. 5C).
Curated By
- BioGRID