S1PR1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- T cell migration [IMP]
- actin cytoskeleton reorganization [IMP]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IDA, ISO]
- angiogenesis [IDA]
- blood vessel maturation [IMP]
- brain development [IMP]
- cardiac muscle tissue growth involved in heart morphogenesis [IMP]
- cell migration [IMP]
- chemotaxis [IMP]
- heart trabecula morphogenesis [IMP]
- lamellipodium assembly [IMP]
- negative regulation of stress fiber assembly [ISO]
- positive regulation of Ras GTPase activity [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of bone mineralization [IMP]
- regulation of bone resorption [IMP]
- regulation of cell adhesion [IDA]
- sphingosine-1-phosphate signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
JAK2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- JAK-STAT cascade [IDA, IMP, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, IMP, ISO]
- STAT protein import into nucleus [IDA]
- activation of JAK2 kinase activity [IDA]
- activation of MAPKK activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IDA]
- axon regeneration [ISO]
- cell differentiation [IMP]
- cell migration [IBA]
- cellular response to dexamethasone stimulus [IDA]
- cellular response to lipopolysaccharide [IDA]
- cytokine-mediated signaling pathway [IMP, ISO, TAS]
- enzyme linked receptor protein signaling pathway [IDA]
- erythrocyte differentiation [IMP]
- extrinsic apoptotic signaling pathway [IDA]
- growth hormone receptor signaling pathway [ISO]
- histone H3-Y41 phosphorylation [IBA, ISO]
- hormone-mediated signaling pathway [ISO]
- host programmed cell death induced by symbiont [IDA]
- inflammatory response [IBA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- mammary gland epithelium development [IMP]
- mineralocorticoid receptor signaling pathway [ISO]
- myeloid cell differentiation [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of neuron apoptotic process [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IMP]
- positive regulation of cell activation [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of growth hormone receptor signaling pathway [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of interleukin-1 beta production [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- protein autophosphorylation [IDA, ISO]
- regulation of cell adhesion [IBA]
- regulation of inflammatory response [ISO]
- response to antibiotic [ISO]
- response to granulocyte macrophage colony-stimulating factor [NAS]
- response to hydroperoxide [ISO]
- response to interleukin-12 [ISO]
- response to lipopolysaccharide [IDA]
- response to oxidative stress [ISO]
- response to tumor necrosis factor [ISO]
- signal transduction [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- tyrosine phosphorylation of STAT protein [IDA, IMP]
- tyrosine phosphorylation of Stat1 protein [ISO]
- tyrosine phosphorylation of Stat3 protein [ISO]
- tyrosine phosphorylation of Stat5 protein [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.
Interleukin-6 (IL-6)-Janus kinase (JAK) signaling is viewed as crucial for persistent signal transducer and activator of transcription-3 (STAT3) activation in cancer. However, IL-6-induced STAT3 activation is normally transient. Here we identify a key mechanism for persistent STAT3 activation in tumor cells and the tumor microenvironment. We show that expression of sphingosine-1-phosphate receptor-1 (S1PR1), a G protein-coupled receptor for the lysophospholipid ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| JAK2 S1PR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID