SLI15
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BIM1
Gene Ontology Biological Process
- microtubule depolymerization [IMP]
- microtubule nucleation [IPI]
- mitotic sister chromatid cohesion [IGI, IMP]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of microtubule depolymerization [IMP]
- nuclear migration along microtubule [IMP]
- positive regulation of microtubule polymerization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Spatiotemporal regulation of ipl1/aurora activity by direct cdk1 phosphorylation.
Oscillating cyclin-dependent kinase 1 (Cdk1) activity is the major regulator of cell-cycle progression [1], whereas the Aurora B kinase, as part of the chromosome passenger complex (CPC), controls critical aspects of mitosis such as chromosome condensation and biorientation on the spindle [2]. How these kinases mechanistically coordinate their important functions is only partially understood. Here, using budding yeast, we identify ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112) [synthetic lethality (APO:0000183)]
Additional Notes
- figure S3C.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
BIM1 SLI15 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
BIM1 SLI15 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.471 | BioGRID | 2039328 | |
BIM1 SLI15 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low/High | - | BioGRID | 438940 | |
BIM1 SLI15 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
SLI15 BIM1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID