BAIT

ATL1

AD-FSP, FSP1, GBP3, HSN1D, SPG3, SPG3A, atlastin1
atlastin GTPase 1
Homo sapiens
PREY

SEY1

dynamin-like GTPase SEY1, YOR165W
Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.

Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA

The endoplasmic reticulum (ER) forms a network of tubules and sheets that requires homotypic membrane fusion to be maintained. In metazoans, this process is mediated by dynamin-like guanosine triphosphatases (GTPases) called atlastins (ATLs), which are also required to maintain ER morphology. Previous work suggested that the dynamin-like GTPase Sey1p was needed to maintain ER morphology in Saccharomyces cerevisiae. In this ... [more]

J. Cell Biol. Apr. 16, 2012; 197(2);209-17 [Pubmed: 22508509]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: synthetic rescue (APO:0000184) [synthetic rescue (APO:0000184)]

Additional Notes

  • figure 1. human Atl1 can partially restore ER morphology, which is abnormal in sey1 yop1 double mutant. growth defect or rescue was not shown though.

Curated By

  • BioGRID