BAIT

ATL1

AD-FSP, FSP1, GBP3, HSN1D, SPG3, SPG3A, atlastin1
atlastin GTPase 1
Homo sapiens
PREY

YOP1

YIP2, L000004674, YPR028W
Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress
Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.

Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA

The endoplasmic reticulum (ER) forms a network of tubules and sheets that requires homotypic membrane fusion to be maintained. In metazoans, this process is mediated by dynamin-like guanosine triphosphatases (GTPases) called atlastins (ATLs), which are also required to maintain ER morphology. Previous work suggested that the dynamin-like GTPase Sey1p was needed to maintain ER morphology in Saccharomyces cerevisiae. In this ... [more]

J. Cell Biol. Apr. 16, 2012; 197(2);209-17 [Pubmed: 22508509]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: synthetic rescue (APO:0000184) [synthetic rescue (APO:0000184)]

Additional Notes

  • figure 1. human Atl1 can partially restore ER morphology, which is abnormal in sey1 yop1 double mutant. growth defect or rescue was not shown though.

Curated By

  • BioGRID