BAIT
WNT1
Int-1, Wnt-1, sw, swaying
wingless-type MMTV integration site family, member 1
GO Process (49)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- Spemann organizer formation [IMP]
- T cell differentiation in thymus [IDA]
- Wnt signaling pathway [IDA, ISO]
- bone development [ISO]
- branching involved in ureteric bud morphogenesis [IGI]
- canonical Wnt signaling pathway [IDA, IGI, ISO]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- cell-cell signaling [IDA, TAS]
- central nervous system morphogenesis [IMP]
- cerebellum formation [IMP]
- diencephalon development [IGI]
- embryonic axis specification [IMP]
- forebrain anterior/posterior pattern specification [IGI]
- hematopoietic stem cell proliferation [IDA]
- hepatocyte differentiation [ISO]
- inner ear morphogenesis [IGI]
- metencephalon development [IMP]
- midbrain development [IMP]
- midbrain-hindbrain boundary development [IMP]
- midbrain-hindbrain boundary maturation during brain development [IMP]
- myoblast fusion [IDA, IGI]
- myotube differentiation [IGI]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of cell aging [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of fat cell differentiation [IDA, IMP]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- neuron fate commitment [IMP]
- neuron fate determination [IMP]
- organ morphogenesis [TAS]
- organ regeneration [ISO]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of dermatome development [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- signal transduction [TAS]
- signal transduction in response to DNA damage [ISO]
- spinal cord association neuron differentiation [IGI]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WNT3A
Wnt-3a, vt, RP23-378H5.2
wingless-type MMTV integration site family, member 3A
GO Process (66)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- COP9 signalosome assembly [IDA]
- Wnt signaling pathway [IGI]
- Wnt signaling pathway involved in forebrain neuroblast division [IMP]
- anterior/posterior pattern specification [IDA]
- axis elongation involved in somitogenesis [IGI]
- axon guidance [IDA]
- axonogenesis [IDA, IGI]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [ISO]
- cardiac muscle cell fate commitment [IGI]
- cell proliferation in forebrain [IDA]
- cell-cell signaling [TAS]
- cellular protein localization [IDA]
- determination of left/right symmetry [IMP]
- dorsal/ventral neural tube patterning [IMP]
- extracellular matrix organization [IDA]
- heart looping [IMP]
- hemopoiesis [IDA]
- hippocampus development [IMP]
- in utero embryonic development [IMP]
- inner ear morphogenesis [IGI]
- mammary gland development [IDA]
- mesoderm development [IMP]
- negative regulation of axon extension involved in axon guidance [IDA]
- negative regulation of fat cell differentiation [IDA, IGI]
- negative regulation of heart induction by canonical Wnt signaling pathway [ISO]
- negative regulation of neurogenesis [IDA]
- negative regulation of neuron projection development [IDA]
- organ morphogenesis [TAS]
- osteoblast differentiation [IGI]
- palate development [ISO]
- paraxial mesodermal cell fate commitment [IMP]
- platelet activation [IDA]
- platelet aggregation [IDA]
- positive regulation of B cell proliferation [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA, ISO]
- positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [IDA]
- positive regulation of cardiac muscle cell differentiation [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell-cell adhesion mediated by cadherin [IDA]
- positive regulation of collateral sprouting in absence of injury [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of cytokine production [IDA]
- positive regulation of dermatome development [ISO]
- positive regulation of mesodermal cell fate specification [ISO]
- positive regulation of neural precursor cell proliferation [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [IGI]
- positive regulation of receptor activity [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- post-anal tail morphogenesis [IMP]
- regulation of axonogenesis [IGI]
- regulation of cell differentiation [IDA]
- regulation of microtubule cytoskeleton organization [IGI]
- signal transduction [TAS]
- skeletal muscle cell differentiation [IGI]
- somatic stem cell division [IDA]
- somitogenesis [IMP]
- spinal cord association neuron differentiation [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord.
In the developing spinal cord, signals from the roof plate are required for the development of three classes of dorsal interneuron: D1, D2, and D3, listed from dorsal to ventral. Here, we demonstrate that absence of Wnt1 and Wnt3a, normally expressed in the roof plate, leads to diminished development of D1 and D2 neurons and a compensatory increase in D3 ... [more]
Genes Dev. Mar. 01, 2002; 16(5);548-53 [Pubmed: 11877374]
Throughput
- Low Throughput
Ontology Terms
- abnormal dorsal root ganglion morphology (MP:0000961) [abnormal dorsal root ganglion morphology (MP:0000961)]
Additional Notes
- figure 1. double mutant enhanced the expression of D3 neurons marker Pax2.
- figure 1. double mutant reduced the expression of D1 neurons marker LH2 and D2 neurons marker Islet1. In double mutant embryos, only trace cell populations expressing LH2 or Islet1 remained at the dorsal margin of the neural tube, indicating that D1 and D2 neurons were largely absent.
- figure 2. In double mutant, dorsal neural progenitors expressing Math1 or Ngn1 were greatly reduced in number (to 15%).
Curated By
- BioGRID