BAIT
CRKL
v-crk avian sarcoma virus CT10 oncogene homolog-like
GO Process (5)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PLSCR1
MMTRA1B
phospholipid scramblase 1
GO Process (14)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- acute-phase response [ISS]
- apoptotic process [IDA]
- defense response to virus [IMP]
- negative regulation of viral genome replication [IMP]
- phosphatidylserine biosynthetic process [ISS]
- phospholipid scrambling [IDA]
- platelet activation [NAS]
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of innate immune response [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [ISS]
- regulation of mast cell activation [ISS]
- response to interferon-beta [IMP]
Gene Ontology Molecular Function- CD4 receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SH3 domain binding [IDA]
- calcium ion binding [IDA, NAS]
- enzyme binding [IPI]
- epidermal growth factor receptor binding [IPI]
- phospholipid scramblase activity [IDA]
- protein binding [IPI]
- CD4 receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SH3 domain binding [IDA]
- calcium ion binding [IDA, NAS]
- enzyme binding [IPI]
- epidermal growth factor receptor binding [IPI]
- phospholipid scramblase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease that shows minimal response to chemotherapy. Genetic changes involved in the progression of PDAC concern genes that encode proteins related to signal transduction networks. This fact reveals the importance in identifying the role and the relations between multiple signaling cascades in PDAC. One of the major factors that modulate signaling events is ... [more]
Proteomics Aug. 01, 2008; 8(15);3071-81 [Pubmed: 18654987]
Throughput
- Low Throughput
Curated By
- BioGRID