BAIT
TRP53BP1
53BP1, Tp53bp1, m53BP1, p53BP1, RP23-437L13.2
transformation related protein 53 binding protein 1
GO Process (5)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- damaged DNA binding [IDA]
- methylated histone binding [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- telomeric DNA binding [IDA]
- transcription factor binding [TAS]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- damaged DNA binding [IDA]
- methylated histone binding [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- telomeric DNA binding [IDA]
- transcription factor binding [TAS]
Gene Ontology Cellular Component
Mus musculus
PREY
NBN
Nbs1, RP23-386N10.1
nibrin
GO Process (18)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- DNA damage checkpoint [ISO]
- DNA duplex unwinding [ISO]
- blastocyst growth [IMP]
- cell proliferation [IMP]
- double-strand break repair [ISO]
- in utero embryonic development [IMP]
- intrinsic apoptotic signaling pathway [IMP]
- isotype switching [IDA]
- mitotic G2 DNA damage checkpoint [IMP, ISO]
- mitotic cell cycle checkpoint [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of viral entry into host cell [ISO]
- neuromuscular process controlling balance [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of kinase activity [ISO]
- positive regulation of protein autophosphorylation [ISO]
- regulation of fibroblast proliferation [ISO]
- telomere maintenance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.
Variable, diversity and joining (V(D)J) recombination and class-switch recombination use overlapping but distinct non-homologous end joining pathways to repair DNA double-strand-break intermediates. 53BP1 is a DNA-damage-response protein that is rapidly recruited to sites of chromosomal double-strand breaks, where it seems to function in a subset of ataxia telangiectasia mutated (ATM) kinase-, H2A histone family member X (H2AX, also known as ... [more]
Nature Nov. 27, 2008; 456(7221);529-33 [Pubmed: 18931658]
Throughput
- Low Throughput
Ontology Terms
- absent lymphocyte (MP:0000726) [absent lymphocyte (MP:0000726)]
Additional Notes
- figure 1a. double mutant enhanced the aberrant levels of T-cell antigen receptor (TCR)-a observed in single mutants.
Curated By
- BioGRID