PTPRF
Gene Ontology Biological Process
- cell migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytokine-mediated signaling pathway [ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of neurotrophin TRK receptor signaling pathway [ISO]
- negative regulation of receptor binding [ISO]
- nervous system development [ISO]
- neuron projection regeneration [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- protein dephosphorylation [ISO]
- regulation of axon regeneration [IMP]
- regulation of neuron projection development [IMP]
- regulation of synapse structure or activity [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
FYN
Gene Ontology Biological Process
- T cell receptor signaling pathway [IBA, ISO]
- activated T cell proliferation [IMP]
- cell surface receptor signaling pathway [IDA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- dendrite morphogenesis [IMP]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- forebrain development [IGI, IMP]
- innate immune response [IBA]
- myelination [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [IMP]
- neuron migration [IGI, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of neuron projection development [IGI]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein localization to nucleus [IDA]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IMP]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of cell shape [IDA]
- response to ethanol [IGI]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- G-protein coupled receptor binding [IPI]
- T cell receptor binding [ISO]
- ephrin receptor binding [ISO]
- glycoprotein binding [ISO]
- growth factor receptor binding [ISO]
- ion channel binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [ISO]
- tubulin binding [IDA]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- G-protein coupled receptor binding [IPI]
- T cell receptor binding [ISO]
- ephrin receptor binding [ISO]
- glycoprotein binding [ISO]
- growth factor receptor binding [ISO]
- ion channel binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [ISO]
- tubulin binding [IDA]
Gene Ontology Cellular Component
Biochemical Activity (Dephosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.
Reactive oxygen species (ROS) have been implicated in vascular smooth muscle cell (VSMC) apoptosis, a hallmark of advanced atherosclerotic lesions. Transient oxidation and inactivation of protein-tyrosine phosphatases play a critical role in cellular response to ROS production. However, the function of leukocyte antigen-related (LAR) protein-tyrosine phosphatase in ROS signaling is not known. To determine the expression of LAR in ROS-induced ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6C.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPRF FYN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 657646 |
Curated By
- BioGRID