BAIT
PPA1
SPAC823.15
minor serine/threonine protein phosphatase Ppa1
GO Process (3)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Schizosaccharomyces pombe (972h)
PREY
PPA2
SPBC16H5.07c
serine/threonine protein phosphatase Ppa2
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Characterisation of ypa1 and ypa2, the Schizosaccharomyces pombe orthologues of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.
The Schizosaccharomyces pombe septation initiation network regulates cytokinesis. Cdc7p is the first kinase in the core septation initiation network; we have screened genetically for SIN regulators by isolating cold-sensitive suppressors of cdc7-24. Our screen yielded a mutant in SPAC1782.05, one of the two fission yeast orthologues of mammalian phosphotyrosyl phosphatase activator. We have characterised this gene and its orthologue SPAC4F10.04, ... [more]
Unknown Jan. 20, 2012; 0(0); [Pubmed: 22267499]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID