BAIT

YPA1

SPAC4F10.04, rrd1, SPAC4F10.04
protein phosphatase type 2A regulator, PTPA family Ypa1
GO Process (0)
GO Function (1)
GO Component (3)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

YPA2

SPAC1782.05, pta2, SPAC1782.05
protein phosphatase type 2A regulator, PTPA family Ypa2
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Characterisation of ypa1 and ypa2, the Schizosaccharomyces pombe orthologues of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Goyal A, Simanis V

The Schizosaccharomyces pombe septation initiation network regulates cytokinesis. Cdc7p is the first kinase in the core septation initiation network; we have screened genetically for SIN regulators by isolating cold-sensitive suppressors of cdc7-24. Our screen yielded a mutant in SPAC1782.05, one of the two fission yeast orthologues of mammalian phosphotyrosyl phosphatase activator. We have characterised this gene and its orthologue SPAC4F10.04, ... [more]

Unknown Jan. 20, 2012; 0(0); [Pubmed: 22267499]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID