PRKCA
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- activation of adenylate cyclase activity [ISS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- blood coagulation [TAS]
- desmosome assembly [IMP]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- histone H3-T6 phosphorylation [IDA]
- innate immune response [TAS]
- mRNA metabolic process [TAS]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of glial cell apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle hypertrophy [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of dense core granule biogenesis [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of macrophage differentiation [ISS]
- positive regulation of mitotic cell cycle [IMP]
- protein phosphorylation [IDA]
- regulation of insulin secretion [TAS]
- regulation of platelet aggregation [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to interleukin-1 [IMP]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NR1H2
Gene Ontology Biological Process
- gene expression [TAS]
- negative regulation of cholesterol storage [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [NAS]
- negative regulation of lipid transport [IMP]
- negative regulation of macrophage derived foam cell differentiation [IC]
- negative regulation of pinocytosis [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of cholesterol transport [IDA]
- positive regulation of fatty acid biosynthetic process [IMP]
- positive regulation of lipoprotein lipase activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of triglyceride biosynthetic process [IMP]
- regulation of cholesterol homeostasis [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- ATPase binding [IPI]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- apolipoprotein A-I receptor binding [IPI]
- protein binding [IPI]
- ATPase binding [IPI]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- apolipoprotein A-I receptor binding [IPI]
- protein binding [IPI]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Protein kinase C alpha modulates liver X receptor alpha transactivation.
Liver X receptor alpha (LXRalpha), an oxysterol-activated nuclear hormone receptor, regulates the expression of genes involved in lipid and cholesterol homeostasis and inflammation. We show here that transactivation by LXRalpha in monkey kidney COS-1 (Cos-1) cells is decreased by activation of the protein kinase C (PKC) signaling pathway. In transient co-transfection assays, phorbol myristate acetate (PMA) suppressed LXR-dependent transactivation of ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Curated By
- BioGRID