NR3C1
Gene Ontology Biological Process
- cellular response to steroid hormone stimulus [IDA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
Gene Ontology Cellular Component
NR0B1
Gene Ontology Biological Process
- adrenal gland development [IMP]
- gene expression [TAS]
- gonad development [IMP]
- hypothalamus development [NAS]
- intracellular receptor signaling pathway [IDA, NAS]
- male gonad development [IMP]
- negative regulation of intracellular steroid hormone receptor signaling pathway [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- pituitary gland development [NAS]
- protein localization [IDA]
- steroid biosynthetic process [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- AF-2 domain binding [IPI]
- DNA binding [IDA]
- DNA hairpin binding [IDA]
- RNA binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- steroid hormone receptor binding [IPI]
- transcription corepressor activity [IMP]
- transcription factor binding [IPI]
- AF-2 domain binding [IPI]
- DNA binding [IDA]
- DNA hairpin binding [IDA]
- RNA binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- steroid hormone receptor binding [IPI]
- transcription corepressor activity [IMP]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.
A common feature of nuclear receptor ligand binding domains (LBD) is a helical sandwich fold that nests a ligand binding pocket within the bottom half of the domain. Here we report that the ligand pocket of glucocorticoid receptor (GR) can be continuously extended into the top half of the LBD by binding to deacylcortivazol (DAC), an extremely potent glucocorticoid. It ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 2B. each peptide contains 15 residues.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR3C1 NR0B1 | PCA PCA A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay. | High | - | BioGRID | 2447731 |
Curated By
- BioGRID