BAIT
CEBPA
C/ebpalpha, CBF-A, Cebp
CCAAT/enhancer binding protein (C/EBP), alpha
GO Process (29)
GO Function (16)
GO Component (6)
Gene Ontology Biological Process
- brown fat cell differentiation [IDA]
- cell maturation [IMP]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- cholesterol metabolic process [IMP]
- cytokine-mediated signaling pathway [NAS]
- embryonic placenta development [IGI]
- fat cell differentiation [IDA]
- inner ear development [IDA]
- liver development [IMP]
- lung development [IMP]
- macrophage differentiation [IMP]
- mitochondrion organization [IMP]
- myeloid cell differentiation [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of fat cell differentiation [IDA, ISO]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, ISO, NAS]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [ISO, NAS]
- urea cycle [IDA]
- white fat cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, NAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA, ISO]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, NAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
NCOA3
2010305B15Rik, AW321064, Actr, Aib1, KAT13B, Rac3, Src3, Tram-1, Tram1, bHLHe42, p/Cip, pCip, RP23-120P1.1
nuclear receptor coactivator 3
GO Process (17)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- cellular response to hormone stimulus [IBA]
- developmental growth [IMP]
- histone acetylation [ISO]
- intracellular receptor signaling pathway [IBA]
- labyrinthine layer morphogenesis [IGI]
- mammary gland branching involved in thelarche [IMP]
- multicellular organism growth [IMP]
- negative regulation of apoptotic process [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of intracellular estrogen receptor signaling pathway [ISO]
- positive regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- positive regulation of keratinocyte differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- regulation of RNA biosynthetic process [ISO]
- vagina development [IMP]
Gene Ontology Molecular Function- RNA polymerase II regulatory region DNA binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA]
- estrogen receptor binding [ISO]
- histone acetyltransferase activity [ISO]
- ligand-dependent nuclear receptor binding [IBA, ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA, ISO]
- nuclear hormone receptor binding [IBA, ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein N-terminus binding [ISO]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- RNA polymerase II regulatory region DNA binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA]
- estrogen receptor binding [ISO]
- histone acetyltransferase activity [ISO]
- ligand-dependent nuclear receptor binding [IBA, ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IBA, ISO]
- nuclear hormone receptor binding [IBA, ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein N-terminus binding [ISO]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program.
The white adipocyte is at the center of dysfunctional regulatory pathways in various pathophysiological processes, including obesity, diabetes, inflammation, and cancer. Here, we show that the oncogenic steroid receptor coactivator-3 (SRC-3) is a critical regulator of white adipocyte development. Indeed, in SRC-3(-/-) mouse embryonic fibroblasts, adipocyte differentiation was severely impaired, and reexpression of SRC-3 was able to restore it. The ... [more]
Proc. Natl. Acad. Sci. U.S.A. Nov. 21, 2006; 103(47);17868-73 [Pubmed: 17098861]
Throughput
- Low Throughput
Additional Notes
- figure 4B.
- figure 4C. Co-localization on PPARg2 promoter determined by ChIP.
Curated By
- BioGRID