KAT5
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [ISO]
- cellular response to estradiol stimulus [ISO]
- double-strand break repair [ISO]
- histone acetylation [ISO]
- negative regulation of interleukin-2 production [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- regulation of transcription, DNA-templated [IDA]
- response to ionizing radiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLA2G4A
Gene Ontology Biological Process
- arachidonic acid metabolic process [ISO]
- arachidonic acid secretion [IDA, IMP]
- cellular response to antibiotic [IDA]
- decidualization [ISO]
- icosanoid biosynthetic process [IMP]
- ovulation from ovarian follicle [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of prostaglandin biosynthetic process [ISO]
- positive regulation of vesicle fusion [ISO]
- regulation of cell proliferation [IGI]
- response to calcium ion [ISO]
- response to organic substance [ISO]
- surfactant homeostasis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
cPLA2-interacting protein, PLIP, causes apoptosis and decreases G1 phase in mesangial cells.
The balance between proliferation and apoptosis of mesangial cells is a critical component of proliferative glomerulonephritis. The regulation of cell proliferation and apoptosis is linked at the level of the cell cycle (Shankland SJ. Kidney Int 52: 294-308, 199). cPLA2-interacting protein (PLIP), the Tip60 splice variant, interacts with cPLA2 and enhances the susceptibility of renal mesangial cells to serum deprivation-induced ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 3C. PLIP is a splice valiant of TIP60.
Curated By
- BioGRID