SRC
Gene Ontology Biological Process
- bone resorption [IMP]
- branching involved in mammary gland duct morphogenesis [IMP]
- cell migration [IMP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- epidermal growth factor receptor signaling pathway [IBA]
- forebrain development [IGI]
- innate immune response [IBA]
- intracellular signal transduction [IGI]
- negative regulation of extrinsic apoptotic signaling pathway [IBA]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- oogenesis [IMP]
- osteoclast development [IGI]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of podosome assembly [IDA, IGI]
- progesterone receptor signaling pathway [IBA]
- protein phosphorylation [IDA]
- regulation of cell cycle [IBA]
- regulation of cell projection assembly [IGI]
- regulation of cell proliferation [IBA]
- regulation of intracellular estrogen receptor signaling pathway [IMP]
- regulation of protein binding [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- uterus development [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
KHDRBS1
Gene Ontology Biological Process
- cell surface receptor signaling pathway [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of RNA export from nucleus [ISO]
- positive regulation of signal transduction [IPI]
- positive regulation of translational initiation [ISO]
- regulation of RNA export from nucleus [IDA]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling.
We recently demonstrated that the chemokine CXCL16 is expressed in aortic smooth muscle cells (ASMC) and induces ASMC adhesion and proliferation (Chandrasekar, B., Bysani, S., and Mummidi, S. (2004) J. Biol. Chem. 279, 3188-3196). Here we reort that interleukin (IL)-18 positively regulates CXCL16 transcription in rat ASMC. We characterized the cis-regulatory region of CXCL16 and identified a functional activator protein-1 ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRC KHDRBS1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 692272 |
Curated By
- BioGRID