BAIT
MCM2
MCM DNA helicase complex subunit MCM2, L000001038, YBL023C
Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
GO Process (6)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- DNA strand elongation involved in DNA replication [IMP]
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via break-induced replication [IMP]
- negative regulation of ATP-dependent DNA helicase activity [IDA]
- nuclear DNA replication [IMP]
- pre-replicative complex assembly involved in nuclear cell cycle DNA replication [IDA, IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
PEP3
VAM8, VPS18, VPT18, tethering complex subunit PEP3, L000001374, L000002473, YLR148W
Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Mcm2 phosphorylation and the response to replicative stress.
ABSTRACT: BACKGROUND: The replicative helicase in eukaryotic cells is comprised of minichromosome maintenance (Mcm) proteins 2 through 7 (Mcm2-7) and is a key target for regulation of cell proliferation. In addition, it is regulated in response to replicative stress. One of the protein kinases that targets Mcm2-7 is the Dbf4-dependent kinase Cdc7 (DDK). In a previous study, we showed that ... [more]
Unknown May. 07, 2012; 13(1);36 [Pubmed: 22564307]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- identified by SGA and confirmed by tetrad analysis
Curated By
- BioGRID