BAIT
CCNE1
CCNE
cyclin E1
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TUBG1
CDCBM4, GCP-1, TUBG, TUBGCP1
tubulin, gamma 1
GO Process (4)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry.
Excess cyclin E-Cdk2 accelerates entry into S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells. We identified 20 amino acids in cyclin E as a centrosomal localization signal (CLS) essential for both centrosomal targeting and promoting DNA synthesis. Expressed wild-type, but not mutant, CLS peptides localized on the centrosome, prevented endogenous ... [more]
Science Oct. 29, 2004; 306(5697);885-8 [Pubmed: 15514162]
Throughput
- Low Throughput
Additional Notes
- figure 1C. centrosomal fractions.
Curated By
- BioGRID