BAIT

H2AFX

AW228881, H2A.X, H2ax, Hist5-2ax, gammaH2ax

H2A histone family, member X

GO Process (6)

GO Function (4)

GO Component (11)

Gene Ontology Biological Process

DNA damage checkpoint [IMP]

DNA repair [IDA, IMP]

cellular response to DNA damage stimulus [ISO]

cellular response to gamma radiation [ISO]

double-strand break repair via homologous recombination [IMP]

spermatogenesis [IMP]

Gene Ontology Molecular Function

damaged DNA binding [IDA]
enzyme binding [ISO]
histone binding [ISO]
protein binding [IPI]

Gene Ontology Cellular Component

chromatin [IDA]

chromosome [IDA]

chromosome, telomeric region [ISO]

condensed nuclear chromosome [IDA]

extracellular vesicular exosome [ISO]

male germ cell nucleus [IDA]

nuclear chromatin [IDA]

nucleus [IDA, ISO]

replication fork [IDA]

site of double-strand break [IDA, ISO]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

TRP53BP1

53BP1, Tp53bp1, m53BP1, p53BP1, RP23-437L13.2

transformation related protein 53 binding protein 1

GO Process (5)

GO Function (9)

GO Component (6)

Gene Ontology Biological Process

DNA repair [IDA]

cellular response to DNA damage stimulus [ISO]

positive regulation of transcription from RNA polymerase II promoter [ISO]

regulation of transcription, DNA-templated [TAS]

transcription from RNA polymerase II promoter [ISO]

Gene Ontology Molecular Function

RNA polymerase II activating transcription factor binding [ISO]
RNA polymerase II transcription cofactor activity [ISO]
damaged DNA binding [IDA]
methylated histone binding [ISO]
p53 binding [ISO]
protein binding [IPI]
sequence-specific DNA binding [IDA]
telomeric DNA binding [IDA]
transcription factor binding [TAS]

Gene Ontology Cellular Component

chromosome, telomeric region [ISO]

cytoplasm [ISO]

kinetochore [IDA]

nucleoplasm [ISO]

nucleus [IDA, ISO]

replication fork [IDA]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A

Histone H2AX is rapidly phosphorylated in the chromatin micro-environment surrounding a DNA double-strand break (DSB). Although H2AX deficiency is not detrimental to life, H2AX is required for the accumulation of numerous essential proteins into irradiation induced foci (IRIF). However, the relationship between IRIF formation, H2AX phosphorylation (gamma-H2AX) and the detection of DNA damage is unclear. Here, we show that the ... [more]

Nat. Cell Biol. Jul. 01, 2003; 5(7);675-9 [Pubmed: 12792649]

Throughput

Low Throughput

Additional Notes

figure 1. recruitment of 53BP1 to DSBs is h2AX-independent.

Curated By

BioGRID