DYN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DMA2
Gene Ontology Biological Process
- cellular bud neck septin ring organization [IGI]
- establishment of mitotic spindle orientation [IGI]
- mitotic spindle orientation checkpoint [IGI]
- protein autoubiquitination [IDA]
- protein localization to bud neck [IGI]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IGI]
- septin ring assembly [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Budding yeast dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the elm1 kinase to the bud neck.
The first step towards cytokinesis in budding yeast is the assembly of a septin ring at the future site of bud emergence. Integrity of this ring is crucial for cytokinesis, proper spindle positioning, and the spindle position checkpoint (SPOC). This checkpoint delays mitotic exit and cytokinesis as long as the anaphase spindle does not properly align with the division axis. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- genetic complex
- rts1/dyn1/dma1/dma2 quadruple mutants are lethal
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DYN1 DMA2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 659109 | |
DYN1 DMA2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 162841 |
Curated By
- BioGRID