CDK4
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- circadian rhythm [IEP]
- lens development in camera-type eye [IEP]
- negative regulation of cell cycle arrest [ISO, ISS]
- organ regeneration [IEP]
- positive regulation of G2/M transition of mitotic cell cycle [ISO, ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cell size [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of translation [IMP]
- protein phosphorylation [ISO]
- regulation of cell cycle [ISO]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- response to drug [ISO]
- response to hyperoxia [IEP]
- response to lead ion [IMP]
- response to organic substance [IMP]
- response to testosterone [IDA]
- response to toxic substance [IEP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KRAS
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- Ras protein signal transduction [ISO]
- actin cytoskeleton organization [ISO]
- cytokine-mediated signaling pathway [IMP]
- epithelial tube branching involved in lung morphogenesis [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of Rac protein signal transduction [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of nitric-oxide synthase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission, GABAergic [ISO]
- response to glucocorticoid [IEP]
- response to mineralocorticoid [IEP]
- social behavior [IEP]
- striated muscle cell differentiation [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2.
Fibroblast growth factor (FGF) and its receptor (FGFR) are thought to be negative regulators of chondrocytic growth, as exemplified by achondroplasia and related chondrodysplasias, which are caused by constitutively active mutations in FGFR3. To understand the growth-inhibitory mechanisms of FGF, we analyzed the effects of FGF2 on cell cycle-regulating molecules in chondrocytes. FGF2 dramatically inhibited proliferation of rat chondrosarcoma (RCS) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID