CCNE1
Gene Ontology Biological Process
- DNA replication initiation [ISO]
- Wnt signaling pathway [ISO]
- antral ovarian follicle growth [IEP]
- cellular response to nutrient [IEP]
- liver development [IEP]
- organ regeneration [IEP]
- positive regulation of cell differentiation [IDA]
- protein phosphorylation [ISO]
- regulation of cell cycle [ISO]
- regulation of protein kinase activity [ISO]
- response to corticosterone [IEP]
- response to cytokine [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to ethanol [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to progesterone [IEP]
- response to purine-containing compound [IEP]
- response to steroid hormone [IEP]
- response to vitamin E [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDK2
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- Ras protein signal transduction [ISO]
- cellular response to insulin stimulus [IDA]
- histone phosphorylation [ISO]
- lens development in camera-type eye [IEP]
- organ regeneration [IEP]
- positive regulation of DNA-dependent DNA replication initiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- potassium ion transport [ISO]
- protein phosphorylation [ISO]
- regulation of cell cycle [IDA, ISO]
- regulation of gene silencing [ISO]
- response to cAMP [IDA]
- response to cadmium ion [IEP]
- response to drug [IEP]
- response to electrical stimulus [IDA]
- response to estradiol [IEP]
- response to ethanol [IEP]
- response to toxic substance [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Cajal body [ISO]
- X chromosome [ISO]
- Y chromosome [ISO]
- chromosome, telomeric region [ISO]
- condensed chromosome [ISO]
- cyclin-dependent protein kinase holoenzyme complex [ISO]
- cytoplasm [ISO]
- cytosol [IDA]
- endosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- nucleus [IDA, ISO]
- transcription factor complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2.
Fibroblast growth factor (FGF) and its receptor (FGFR) are thought to be negative regulators of chondrocytic growth, as exemplified by achondroplasia and related chondrodysplasias, which are caused by constitutively active mutations in FGFR3. To understand the growth-inhibitory mechanisms of FGF, we analyzed the effects of FGF2 on cell cycle-regulating molecules in chondrocytes. FGF2 dramatically inhibited proliferation of rat chondrosarcoma (RCS) ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CCNE1 CDK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID