BAIT
ITSN1
ITSN, SH3D1A, SH3P17
intersectin 1 (SH3 domain protein)
GO Process (7)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [NAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic vesicle endocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DAB2
DOC-2, DOC2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
GO Process (23)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- cell proliferation [TAS]
- integrin-mediated signaling pathway [IMP]
- leading edge cell differentiation [IMP]
- membrane organization [TAS]
- negative regulation of androgen receptor signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of protein binding [IMP]
- negative regulation of protein localization to plasma membrane [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of clathrin-mediated endocytosis [IMP]
- positive regulation of early endosome to late endosome transport [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- receptor-mediated endocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks.
Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent studies have revealed a more complex role for these scaffold proteins in regulation of additional biochemical pathways. In this study, we performed a high throughput yeast two-hybrid screen to identify ... [more]
PLoS ONE May. 05, 2012; 7(4);e36023 [Pubmed: 22558309]
Throughput
- High Throughput
Curated By
- BioGRID