BAIT
ITSN1
ITSN, SH3D1A, SH3P17
intersectin 1 (SH3 domain protein)
GO Process (7)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [NAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic vesicle endocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PICALM
CALM, CLTH, PAP180, fit-1, fit1, mKIAA4114
phosphatidylinositol binding clathrin assembly protein
GO Process (22)
GO Function (6)
GO Component (18)
Gene Ontology Biological Process
- axonogenesis [IMP, ISO]
- cargo loading into vesicle [ISO]
- cell proliferation [ISO]
- clathrin coat assembly [ISO]
- clathrin-mediated endocytosis [ISO]
- dendrite morphogenesis [IMP, ISO]
- endosomal transport [ISO]
- hemopoiesis [IMP]
- iron ion homeostasis [ISO]
- iron ion import into cell [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of receptor-mediated endocytosis [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- regulation of endocytosis [ISO]
- regulation of protein localization [ISO]
- regulation of protein transport [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-2 adaptor complex [ISO]
- clathrin coat of coated pit [ISO]
- clathrin-coated vesicle [ISO]
- coated pit [IDA, ISO]
- endosome [ISO]
- intracellular [IDA]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- neurofibrillary tangle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
- synapse [ISO]
- synaptic vesicle [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks.
Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent studies have revealed a more complex role for these scaffold proteins in regulation of additional biochemical pathways. In this study, we performed a high throughput yeast two-hybrid screen to identify ... [more]
PLoS ONE May. 05, 2012; 7(4);e36023 [Pubmed: 22558309]
Throughput
- High Throughput
Curated By
- BioGRID