BAIT
ITSN1
ITSN, SH3D1A, SH3P17
intersectin 1 (SH3 domain protein)
GO Process (7)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [NAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic vesicle endocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BECN1
4921513J16Rik, 5430417M23Rik, Atg6, RP23-281C18.12-004
beclin 1, autophagy related
GO Process (17)
GO Function (1)
GO Component (13)
Gene Ontology Biological Process
- CVT pathway [IBA]
- autophagic vacuole assembly [IBA, ISO]
- autophagy [IDA, IMP, ISO]
- beta-amyloid metabolic process [IMP]
- cellular response to nitrogen starvation [IBA]
- cytokinesis [ISO]
- late endosome to vacuole transport [IBA]
- lysosome organization [IMP]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IDA]
- neuron development [IMP]
- nucleophagy [IBA]
- positive regulation of autophagy [ISO]
- positive regulation of macroautophagy [IGI]
- positive regulation of mitochondrion degradation [ISO]
- regulation of catalytic activity [IMP]
- response to other organism [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoskeleton [ISS]
- dendrite [ISO]
- extrinsic component of membrane [IBA]
- membrane [ISS]
- nucleus [ISO]
- phagocytic vesicle [IDA]
- phosphatidylinositol 3-kinase complex, class III, type I [IBA]
- phosphatidylinositol 3-kinase complex, class III, type II [IBA]
- pre-autophagosomal structure [IBA]
- protein complex [IDA]
- trans-Golgi network [IDA]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks.
Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent studies have revealed a more complex role for these scaffold proteins in regulation of additional biochemical pathways. In this study, we performed a high throughput yeast two-hybrid screen to identify ... [more]
PLoS ONE May. 05, 2012; 7(4);e36023 [Pubmed: 22558309]
Throughput
- High Throughput
Curated By
- BioGRID