BAIT
ITSN1
ITSN, SH3D1A, SH3P17
intersectin 1 (SH3 domain protein)
GO Process (7)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [NAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic vesicle endocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SPRY2
sprouty2
sprouty homolog 2 (Drosophila)
GO Process (24)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- bud elongation involved in lung branching [IGI]
- cell fate commitment [IGI, IMP]
- establishment of mitotic spindle orientation [IGI]
- inner ear morphogenesis [IGI, IMP]
- lung development [IMP]
- lung growth [IDA]
- lung morphogenesis [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA, IGI]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of Ras GTPase activity [IDA]
- negative regulation of Ras protein signal transduction [IDA]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA, IGI]
- negative regulation of neurotrophin TRK receptor signaling pathway [IDA]
- negative regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- respiratory system development [IDA]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks.
Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent studies have revealed a more complex role for these scaffold proteins in regulation of additional biochemical pathways. In this study, we performed a high throughput yeast two-hybrid screen to identify ... [more]
PLoS ONE May. 05, 2012; 7(4);e36023 [Pubmed: 22558309]
Throughput
- High Throughput
Curated By
- BioGRID