BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MTRR
MSR, cblE
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
GO Process (12)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- DNA methylation [ISS]
- cellular nitrogen compound metabolic process [TAS]
- cobalamin metabolic process [TAS]
- folic acid metabolic process [ISS]
- methionine metabolic process [TAS]
- methylation [TAS]
- oxidation-reduction process [TAS]
- small molecule metabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- FMN binding [TAS]
- NADP binding [TAS]
- NADPH-hemoprotein reductase activity [IBA]
- [methionine synthase] reductase activity [TAS]
- flavin adenine dinucleotide binding [IDA, TAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [IDA]
- FMN binding [TAS]
- NADP binding [TAS]
- NADPH-hemoprotein reductase activity [IBA]
- [methionine synthase] reductase activity [TAS]
- flavin adenine dinucleotide binding [IDA, TAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID