BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TGFB3
ARVD, ARVD1, RNHF, TGF-beta3
transforming growth factor, beta 3
GO Process (37)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- SMAD protein signal transduction [IBA]
- blood coagulation [TAS]
- cell-cell junction organization [IDA]
- detection of hypoxia [IDA]
- extracellular matrix organization [TAS]
- face morphogenesis [IMP]
- in utero embryonic development [ISS]
- lung alveolus development [ISS]
- mammary gland development [ISS]
- negative regulation of DNA replication [IMP]
- negative regulation of cell proliferation [ISS]
- negative regulation of macrophage cytokine production [IDA]
- negative regulation of neuron apoptotic process [ISS]
- odontogenesis [NAS]
- ossification involved in bone remodeling [IEP]
- palate development [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of DNA replication [IMP]
- positive regulation of SMAD protein import into nucleus [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of bone mineralization [IEP]
- positive regulation of collagen biosynthetic process [IMP]
- positive regulation of epithelial to mesenchymal transition [IDA, ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA, ISS]
- positive regulation of protein secretion [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- response to hypoxia [IDA]
- response to progesterone [IDA]
- salivary gland morphogenesis [IEP]
- transforming growth factor beta receptor signaling pathway [IDA]
- uterine wall breakdown [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID