BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PPM1F
CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2
protein phosphatase, Mg2+/Mn2+ dependent, 1F
GO Process (15)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cellular response to drug [IDA]
- intrinsic apoptotic signaling pathway [IDA]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- peptidyl-threonine dephosphorylation [IDA]
- positive regulation of cell-substrate adhesion [IMP]
- positive regulation of chemotaxis [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of focal adhesion assembly [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of growth [IMP]
- positive regulation of stress fiber assembly [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID