BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SOX4
EVI16
SRY (sex determining region Y)-box 4
GO Process (41)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP]
- T cell differentiation [ISS]
- ascending aorta morphogenesis [ISS]
- atrial septum primum morphogenesis [ISS]
- canonical Wnt signaling pathway [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac ventricle formation [ISS]
- cellular response to glucose stimulus [ISS]
- glial cell development [ISS]
- glial cell proliferation [ISS]
- glucose homeostasis [ISS]
- heart development [ISS]
- kidney morphogenesis [ISS]
- limb bud formation [ISS]
- mitral valve morphogenesis [ISS]
- negative regulation of cell death [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of protein ubiquitination [IMP]
- neural tube formation [ISS]
- neuroepithelial cell differentiation [ISS]
- noradrenergic neuron differentiation [ISS]
- positive regulation of N-terminal peptidyl-lysine acetylation [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of insulin secretion [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of translation [IMP]
- pro-B cell differentiation [ISS]
- protein stabilization [IMP]
- regulation of protein stability [IMP]
- regulation of transcription, DNA-templated [IDA]
- skeletal system development [ISS]
- spinal cord development [ISS]
- spinal cord motor neuron differentiation [ISS]
- sympathetic nervous system development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID