BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
HEY1
BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1
hes-related family bHLH transcription factor with YRPW motif 1
GO Process (24)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [IDA, TAS]
- angiogenesis [IEP]
- arterial endothelial cell differentiation [ISS]
- atrioventricular valve formation [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac septum morphogenesis [ISS]
- cardiac ventricle morphogenesis [ISS]
- dorsal aorta morphogenesis [ISS]
- endocardial cushion morphogenesis [ISS]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- heart trabecula formation [ISS]
- labyrinthine layer blood vessel development [ISS]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [IDA]
- negative regulation of transcription regulatory region DNA binding [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- pulmonary valve morphogenesis [ISS]
- regulation of vasculogenesis [ISS]
- transcription from RNA polymerase II promoter [ISS]
- umbilical cord morphogenesis [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID