BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
GPD1L
GPD1-L
glycerol-3-phosphate dehydrogenase 1-like
GO Process (15)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- NAD metabolic process [IMP]
- cellular lipid metabolic process [TAS]
- glycerophospholipid biosynthetic process [TAS]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of protein kinase C signaling [IMP]
- phosphatidic acid biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- positive regulation of protein localization to cell surface [IMP]
- positive regulation of sodium ion transport [IMP]
- regulation of heart rate [IMP]
- regulation of sodium ion transmembrane transporter activity [IMP]
- regulation of ventricular cardiac muscle cell membrane depolarization [IMP]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID