BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
FOXP1
12CC4, QRF1, hFKH1B, HSPC215
forkhead box P1
GO Process (24)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- T follicular helper cell differentiation [ISS]
- chemokine (C-C motif) ligand 2 secretion [IDA]
- endothelial cell activation [IMP]
- interleukin-21 secretion [ISS]
- macrophage activation [IDA]
- monocyte activation [IDA]
- negative regulation of B cell apoptotic process [IDA]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- osteoclast development [IDA]
- osteoclast differentiation [IDA]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- regulation of defense response to bacterium [IDA]
- regulation of endothelial tube morphogenesis [IMP]
- regulation of inflammatory response [IDA]
- regulation of interleukin-1 beta secretion [IDA]
- regulation of interleukin-12 secretion [IDA]
- regulation of macrophage colony-stimulating factor production [IDA]
- regulation of monocyte differentiation [IDA]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of tumor necrosis factor production [IDA]
- response to lipopolysaccharide [IDA]
- transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID