BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CITED2
ASD8, MRG-1, MRG1, P35SRJ, VSD2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
GO Process (31)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- adrenal cortex formation [ISS]
- cell proliferation [IDA]
- determination of left/right symmetry [ISS]
- embryonic heart tube left/right pattern formation [ISS]
- heart development [IMP, ISS]
- left/right axis specification [ISS]
- liver development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of gene expression [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISS]
- outflow tract morphogenesis [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell-cell adhesion [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of male gonad development [ISS]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- regulation of nucleic acid-templated transcription [IDA]
- regulation of organ formation [ISS]
- response to estrogen [IDA]
- response to fluid shear stress [IMP]
- response to hypoxia [IDA, IMP]
- sex determination [ISS]
- spleen development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- LBD domain binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- chromatin binding [ISS]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IMP]
- LBD domain binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- chromatin binding [ISS]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IMP]
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID