BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TBX3
TBX3-ISO, UMS, XHL
T-box 3
GO Process (21)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- anterior/posterior axis specification, embryo [IMP]
- cell aging [IDA]
- cellular senescence [IDA]
- embryonic digit morphogenesis [IMP]
- embryonic forelimb morphogenesis [IMP]
- female genitalia development [IMP]
- follicle-stimulating hormone secretion [IMP]
- forelimb morphogenesis [IDA]
- luteinizing hormone secretion [IMP]
- male genitalia development [IMP]
- mammary gland development [IMP]
- mesoderm morphogenesis [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [IDA]
- positive regulation of cell cycle [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- skeletal system development [IMP]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID