BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CLN3
BTS, JNCL
ceroid-lipofuscinosis, neuronal 3
GO Process (30)
GO Function (2)
GO Component (20)
Gene Ontology Biological Process
- action potential [ISS]
- amyloid precursor protein catabolic process [IDA]
- arginine transport [IDA]
- associative learning [ISS]
- autophagic vacuole fusion [ISS]
- cellular amino acid metabolic process [ISS]
- ceramide metabolic process [IDA]
- cytosolic calcium ion homeostasis [ISS]
- galactosylceramide metabolic process [IMP]
- globoside metabolic process [IMP]
- glucosylceramide metabolic process [IMP]
- ionotropic glutamate receptor signaling pathway [ISS]
- lysosomal lumen acidification [IMP]
- lysosomal lumen pH elevation [IDA]
- lysosome organization [ISS]
- macroautophagy [NAS]
- membrane organization [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of catalytic activity [ISS]
- negative regulation of macroautophagy [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of proteolysis [ISS]
- neuromuscular process controlling balance [ISS]
- neurotransmitter metabolic process [ISS]
- protein catabolic process [NAS]
- protein processing [ISS]
- receptor-mediated endocytosis [IMP]
- sphingomyelin metabolic process [IMP]
- vacuolar transport [IBA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi membrane [IDA]
- Golgi stack [IDA]
- autophagic vacuole [ISS]
- caveola [IDA]
- cytoplasm [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- integral component of membrane [IDA]
- late endosome [IDA, ISS]
- lysosomal membrane [IDA]
- lysosome [IDA]
- membrane raft [IDA]
- mitochondrion [TAS]
- neuron projection [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- synaptic vesicle [IDA]
- trans-Golgi network [IDA]
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID